Nebivolol: Uses, Interactions, Mechanism of Action

Nebivolol, a treatment for high blood pressure, contains the active substance, Nebivolol, which is a beta-blocker with a vasodilator effect, which works to lower blood pressure, thus reducing the risk of strokes, kidney disease and heart attacks. It also helps in reducing heart rate and blood pressure and reduces pressure on the heart. We will learn together, God willing, come through the suydaly's website, the reasons and contraindications for use, the dose, and the trade name, so follow us.

suydaly Nebivolol

As usual, a detailed explanation of everything that is the case on suydaly's website, as is the case with Nebivol medicine, and some of the information that must be known:
Nebivolol belongs to a class of drugs called beta-blockers.
, which makes the heartbeat and blood pressure.
She forced him to relax.
It prevents the effect of adrenaline on the heart and blood vessels, which helps to lower blood pressure.

What is Nebivolol?

Nebivolol is a medication used in the management and treatment of hypertension.

Nebivolol belongs to the class of beta-1 blockers, and it has little activity on beta-2 receptors, which are mainly found in the muscles of the airways and blood vessels. The heart is slow and regular. It causes blood vessels to relax and widen, and lower blood pressure.
Nebivolol blocks the effect of epinephrine, which is called adrenaline (naturally found in the body), on the heart and blood vessels, which helps lower heart rate and blood pressure and reduces stress on the heart.

What is Nebivolol Plus?

Nebivolol Plus is a medicine used to treat high blood pressure. It contains the active substance nebivolol, which belongs to beta-blockers to lower blood pressure, in addition to the active substance hydrochlorothiazide, which acts as a diuretic.

Uses for Nebivolol

Nebivolol is used for the following reasons:

Treating high blood pressure.
Reduces the risk of strokes, kidney disease and heart attacks, due to its effect on high blood pressure.
It helps lower heart rate and blood pressure and reduces pressure on the heart.

Nebivolol Mechanism of Action

Nebivolol is a beta-1 adrenergic receptor antagonist that works via beta-1 receptor blockade; hence, it classifies as a cardioselective beta-blocker. It also acts on the vascular endothelium by stimulating nitric oxide (NO) synthase, which induces NO-mediated vasodilation. Nebivolol stimulates NO synthase production from the endothelium via beta-3 agonism leading to a reduction in systemic vascular resistance. Beta-blockers, such as labetalol and carvedilol, also have vasodilatory effects; however, their mechanism is via the blockade of alpha-adrenergic receptors. Patients with diabetes mellitus, erectile dysfunction, and vascular disease may have abnormal endothelial function, and nebivolol is more effective in these populations due to its NO-induced vasodilatory effect.
Nebivolol is chemically composed of a racemic mixture of L-nebivolol and D-nebivolol. It is classified as the third-generation beta-1 adrenergic receptor antagonist, with the highest beta-receptor affinity among all beta-blockers explaining its excellent tolerability in patients with lung disease. Nebivolol is unique in terms of its beta-1 vs. beta-1 and beta-2 selectiveness. At low doses of 10 mg or below and in patients with extensive metabolizers, nebivolol is beta-1 selective. However, nebivolol loses its selectivity and blocks beta-1 and beta-2 receptors at higher doses and in patients with poor metabolizers

Contraindications for the use of Nebivolol

Nebivolol should not be used in the following cases:

Hypersensitivity to the active ingredients of the drug.
Heart failure or serious problems with the heart or heart valves that don't allow blood to flow in the right direction.
Third degree atrioventricular block.
Peripheral circulatory disorders.
slow heart rate
Diabetics.
liver disease.
Chronic kidney disease.
Thyroid disorder.
Sick Sinus Syndrome.
Pregnancy or planning pregnancy.

Side effects of Nebivolol

Taking nebivolol may lead to some side effects that differ from one person to another, depending on certain circumstances and its side effects, as follows:

dizziness.
Fatigue and insomnia.
Headache.
Disorders, stomach pain, nausea and diarrhea.
sleep problems
Increased triglyceride levels, insulin resistance, and decreased high-density lipoprotein.
bradycardia
chest pain
shortness of breath.

Nebivolol Precautions and Warnings

You should heed the necessary warnings in these cases.
Your blood pressure should be measured regularly.
coronary artery disease:
Abrupt discontinuation of treatment is contraindicated in this situation because it leads to the emergence of an acute exacerbation of coronary artery disease upon abrupt cessation of treatment.
Diabetics:
Eating deficiency in symptoms of hypoglycemia.

Drug interactions with Nebivolol

You should consult your doctor before taking nebivolol and inform him of the list of drugs that the disease takes before the doctor prescribes this drug for him, in anticipation of drug interactions with nebivolol, and among these drugs:
CYP2D6 inhibitors (fluoxetine, bupropion, paroxetine, amiodarone, propafenone, quinidine) may increase nebivolol levels.
Alpha blockers (such as Prazosin)
Reserpine is an antipsychotic and antihypertensive agent of the indole alkaloid group.
Digitalis glycosides, digoxin disopyramide, guanethidine, and other beta-blockers slow atrioventricular conduction and reduce heart rate, and may increase the risk of bradycardia.
Medicines to lower blood sugar (such as insulin, sulfonylureas such as glyburide).
Non-steroidal anti-inflammatory drugs such as: indomethacin.
Sildenafil treatment of pulmonary arterial hypertension.
Beta-agonists (dobutamine, isopreterenol).
Calcium channel blockers such as verapamil, nifedipine, or diltiazem may cause excessive decreases in heart rate and blood pressure.
Antacids such as: cimetidine.
Vitamins and herbal supplements.
Terbinafine is an antifungal medication.
Asthma and nasal congestion medications such as pseudoephedrine.

Nebivolol and pregnancy

Category C medication, unclear if nebivolol gets excreted in breast milk; however, beta-blockers can cause serious adverse reactions in nursing infants, e.g., bradycardia.
It is recommended that the use of nebivolol be avoided during pregnancy because during the last 3 months of pregnancy it may cause problems in the newborn. Such as low blood pressure, irregular heartbeat, and slow breathing.

Nebivolol and lactation

It is forbidden to take nebivolol during breastfeeding, because it is excreted through breast milk during lactation, and thus the occurrence of some serious side effects in infants, such as slowing the heart rate very much.

Dosage for nebivolol

Nebivolol should not be taken without a doctor's prescription, and unless the doctor prescribes otherwise, the dose of nebivolol is as follows:
Dosage of nebivolol for hypertensive adults over 18 years: Take 5 mg once daily.
The maximum dose may be increased over a two-week period to 40 mg daily as needed
Dosage of nebivolol for patients with chronic heart failure, adults over 18 years old:
The recommended starting dose for patients with chronic heart failure is 1.25 mg daily.
The dose in a patient with chronic heart failure may be increased after one to two weeks to half a tablet daily (2.5 mg) and then to one tablet of 5 mg daily.
It can be increased to the maximum recommended dose (10 mg) or two tablets daily.
The dose of nebivolol for patients with renal or hepatic insufficiency is 2.5 mg.
If you want to increase the dose for a further reduction in blood pressure, wait 2 weeks.
The maximum dose for nebivolol is 40 mg daily.

Brand names nebivolol

Bystolic.
MAVILOR
MODULOL.
NEBASCO.
NEBICARD.
NEBILET.
NEBIMOUN.
NEPVOL.
NEVILOB.
SYMBIAN.
Nebimac.
Nebilife.
Nebicor.
Cardineb.
Important Alert
This drug information is educational information that does not replace a doctor's visit, and the site is not responsible for taking medication without consulting a doctor.

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